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MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting
Luis M De León-Rodríguez1, Angelo Lubag, D Gomika Udugamasooriya
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9185, USA.
Journal of the American Chemical Society
|August 28, 2010
Abstract:
The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo.
