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Mycobacterium tuberculosis Extracellular Vesicle Enrichment through Size Exclusion Chromatography
Published on: May 19, 2022
Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater
Megan Sturdy1, Aleksej Krunic, Sanghyun Cho
1Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Room 539, Chicago, Illinois 60612, USA.
Abstract:
Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacterium Eucapsis sp. (UTEX 1519) by bioassay-guided fractionation. The chemical structure was determined by analyzing MS and 1D and 2D NMR spectroscopic data. Eucapsitrione (1) showed anti-Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low-oxygen-recovery assay with MIC values of 3.1 and 6.4 microM, respectively.

