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Perforated peptic ulcer in southeastern Taiwan.
Chin-Hsien Li1, Wen-Hsiung Chang, Shou-Chuan Shih
1Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Hsinchu Branch, Taiwan.
Journal of Gastroenterology and Hepatology
|August 28, 2010
Summary
This study identified key risk factors for mortality and morbidity in patients with perforated peptic ulcers in southeastern Taiwan. Older age, elevated lipase, and preoperative shock predict mortality, while NSAID use, high creatinine, and shock predict morbidity.
Area of Science:
- Gastroenterology
- Surgical Outcomes
- Epidemiology
Background:
- Limited research exists on perforated peptic ulcers in southeastern Taiwan.
- This study addresses the need to understand racial differences and risk factors in this population.
Purpose of the Study:
- To assess racial disparities in perforated peptic ulcer patients.
- To identify risk factors for mortality and morbidity post-surgery in southeastern Taiwan.
Main Methods:
- Retrospective review of 237 perforated peptic ulcer patient medical records.
- Analysis of patient demographics, clinical data, operative details, and outcomes.
- Multivariate analysis to determine independent predictors of mortality and morbidity.
Main Results:
- Aboriginal patients differed in gender ratio, alcohol/betel nut use, fever, hemoglobin, perforation site, and operative method.
- Overall complication rate was 41.3%; mortality rate was 16.6%.
- Independent predictors of mortality: age ≥ 65, elevated lipase, preoperative shock. Independent predictors of morbidity: NSAID use, creatinine > 1.5 mg/dL, preoperative shock.
Conclusions:
- Significant differences exist between Aboriginal and non-Aboriginal populations regarding perforated peptic ulcers.
- Preoperative shock, NSAID use, and elevated creatinine are key risk factors for morbidity.
- Age, elevated lipase, and preoperative shock are critical risk factors for mortality in this patient group.
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