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Updated: Jun 9, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
07:12

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Published on: January 21, 2020

Central poststroke pain syndrome.

Richard L Harvey1

  • 1Rehabilitation Institute of Chicago, Chicago, Illinois, USA.

Topics in Stroke Rehabilitation
|August 28, 2010
PubMed
Summary
This summary is machine-generated.

Central poststroke pain (CPSP) syndrome, a rare stroke complication, requires interdisciplinary management. While medications offer some relief, motor cortex stimulation (MCS) shows promise for future CPSP treatment.

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Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
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Published on: July 18, 2016

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Last Updated: Jun 9, 2026

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain
07:27

Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain

Published on: July 18, 2016

Area of Science:

  • Neurology
  • Pain Medicine
  • Neurosurgery

Background:

  • Central poststroke pain (CPSP) syndrome is an uncommon yet significant complication following a stroke.
  • It represents a common etiology of central neuropathic pain, impacting patient quality of life.

Purpose of the Study:

  • To review the current management strategies for central poststroke pain (CPSP).
  • To explore the potential of novel therapeutic approaches, including motor cortex stimulation (MCS).

Main Methods:

  • Review of existing literature on CPSP management.
  • Analysis of clinical trial data for motor cortex stimulation (MCS) efficacy.

Main Results:

  • Pharmacological treatments for CPSP exist but lack optimal efficacy.
  • Motor cortex stimulation (MCS), though not yet available in the US, demonstrated good efficacy in trials.
  • A stepwise, individualized medication adjustment approach is crucial for pain control.

Conclusions:

  • Effective CPSP management necessitates a coordinated, interdisciplinary pain program.
  • Motor cortex stimulation (MCS) combined with pharmacotherapy may offer a future treatment avenue for CPSP.