Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Careful planning required for the transition to electronic cause of death registration.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025

Same author

Tracking poison ingestion deaths for South Africa: The need for access to timely reliable data.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025

Same author

Discovery of Crystalline Inorganic Solids in the Digital Age.

Accounts of chemical research·2025

Same author

Effectiveness of cholinium amino acid ionic liquids for the extraction of phytonutrients from palm oil.

Royal Society open science·2025

Same author

Registered COVID deaths in South Africa during the first year of the SARS-CoV-2 epidemic.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024

Same author

The importance of including manner of (injury) death on the death notification form.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2023

Search research articles

Related Experiment Video

Updated: Jun 9, 2026

Fabrication and Characterization of Colorectal Cancer Organoids from SW1222 Cell Line in Ultrashort Self-Assembling Peptide Matrix

Fabrication and Characterization of Colorectal Cancer Organoids from SW1222 Cell Line in Ultrashort Self-Assembling Peptide Matrix

Published on: May 3, 2024

An adaptable peptide-based porous material.

J Rabone¹, Y-F Yue, S Y Chong

¹Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.

Science (New York, N.Y.)

|August 28, 2010

Summary

This summary is machine-generated.

This study introduces a crystalline porous material with adaptable porosity. Its flexible peptide linkers allow pore size to change smoothly with guest loading, mimicking protein conformational changes.

More Related Videos

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Published on: March 6, 2017

Related Experiment Videos

Last Updated: Jun 9, 2026

Fabrication and Characterization of Colorectal Cancer Organoids from SW1222 Cell Line in Ultrashort Self-Assembling Peptide Matrix

Fabrication and Characterization of Colorectal Cancer Organoids from SW1222 Cell Line in Ultrashort Self-Assembling Peptide Matrix

Published on: May 3, 2024

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Insights into the Interactions of Amino Acids and Peptides with Inorganic Materials Using Single-Molecule Force Spectroscopy

Published on: March 6, 2017

Area of Science:

Materials Science
Supramolecular Chemistry
Nanotechnology

Background:

Porous materials are crucial for storage, separation, and catalysis.
Controlling pore size and flexibility in porous materials remains a challenge.

Purpose of the Study:

To develop a crystalline porous solid with adaptable porosity.
To investigate the mechanism of pore volume evolution in response to guest loading.
To explore the analogy between the material's behavior and protein conformational changes.

Main Methods:

Synthesis of a crystalline porous solid using a dipeptide linker and metal centers.
Experimental sorption isotherm measurements.
Molecular dynamics simulations to analyze peptide dynamics and pore conformation changes.

Main Results:

The crystalline porous solid exhibits adaptable porosity.
Low-energy peptide torsions and displacements allow smooth evolution of pore volume with guest loading.
Sorption isotherms show cooperative feedback, similar to protein conformational selection.

Conclusions:

Flexible peptide linkers are key to controlling pore conformation in this material.
The material's adaptable porosity offers a new paradigm for guest-responsive porous systems.
The observed behavior suggests parallels with protein folding energy landscapes.