Related Experiment Video

Updated: Jun 9, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

High-dose isoflavones do not improve metabolic and inflammatory parameters in androgen-deprived men with prostate

Joshua K Napora1, Ryan G Short, Denis C Muller

  • 1National Institute of Health, National Institute on Aging, Laboratory of Clinical Investigation, Diabetes Section, Baltimore, Maryland, USA.

Journal of Andrology
|August 28, 2010
PubMed

Insights

High-dose isoflavones did not improve metabolic or inflammatory parameters in men undergoing androgen deprivation therapy (ADT) for prostate cancer. This 12-week study found no significant differences between soy protein and placebo groups.

Area of Science:

  • Endocrinology
  • Oncology
  • Nutritional Science

Background:

  • Androgen deprivation therapy (ADT) for prostate cancer (PCa) can cause hypogonadism, leading to metabolic syndrome and cardiovascular disease.
  • Phytoestrogens, like isoflavones, have shown potential in improving metabolic health.

Purpose of the Study:

  • To evaluate the effects of high-dose isoflavones on metabolic and inflammatory parameters in men undergoing ADT for PCa.

Main Methods:

  • A 12-week, randomized, double-blind, placebo-controlled pilot study.
  • 33 men undergoing ADT received either 20g soy protein with 160mg isoflavones or a taste-matched placebo.

Main Results:

  • No significant differences were observed in metabolic or inflammatory parameters between the isoflavone and placebo groups after 12 weeks.
  • High-dose isoflavones did not demonstrate a benefit in this cohort.

Conclusions:

  • High-dose isoflavones do not appear to improve metabolic or inflammatory parameters in men undergoing androgen deprivation therapy for prostate cancer.
  • Further research may be needed to explore other phytoestrogens or intervention durations.

More Related Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...