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Updated: Jun 9, 2026
Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
Published on: October 9, 2016
Growth inhibition of Microcystis aeruginosa by a glycolipid-type compound from Bacillus subtilis C1
Hee-Sik Kim1, Chi-Yong Ahn, Seung-Hyun Joung
1Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
Abstract:
We attempted to identify the compound responsible for the growth inhibition of Microcystis aeruginosa occurring when a culture broth of Bacillus subtilis C1 was added to the medium. The active compound was purified from B. subtilis C1 culture broth by adsorption chromatography and HPLC, and was identified as a type of glycolipid based on 1H NMR and MS analyses. The purified active compound completely inhibited the growth of M. aeruginosa at a concentration of 10 microgram/ml. This is the first report of a glycolipid produced by a Bacillus strain that has potential as an agent for the selective control of bloom-forming M. aeruginosa.
