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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

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Published on: November 30, 2016

Chronic renal failure, cachexia, and ghrelin.

A Laviano¹, Z Krznaric, K Sanchez-Lara

¹Department of Clinical Medicine, Sapienza University of Rome, 00185 Rome, Italy.

International Journal of Peptides

|August 28, 2010

Summary

This summary is machine-generated.

Protein energy wasting in chronic kidney disease patients may be improved by ghrelin therapy. Exogenous ghrelin may overcome resistance and boost food intake, enhancing survival in these patients.

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Area of Science:

Nephrology
Endocrinology
Metabolic Disorders

Background:

Protein energy wasting (PEW) is prevalent in advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD).
Anorexia and reduced food intake in CKD patients critically impair survival.
Ghrelin, a stomach-derived peptide, stimulates appetite by acting on hypothalamic orexigenic neurons.

Purpose of the Study:

To investigate the potential of exogenous ghrelin administration to improve food intake and combat PEW in CKD patients.
To explore ghrelin's role in managing anorexia and improving nutritional status in ESRD.

Main Methods:

Review of existing evidence on ghrelin levels and function in CKD patients.
Analysis of studies investigating the effects of exogenous ghrelin administration on food intake.
Assessment of the hypothesis of inflammation-mediated ghrelin resistance in the hypothalamus.

Main Results:

CKD patients exhibit elevated plasma ghrelin levels due to reduced renal clearance.
Despite high ghrelin levels, food intake is reduced, suggesting hypothalamic resistance.
Evidence indicates exogenous ghrelin may overcome this resistance and stimulate appetite.

Conclusions:

Ghrelin administration is a potential therapeutic strategy for PEW in CKD.
Preliminary data are promising, but larger clinical trials are required.
Further research is needed to identify patient subgroups most likely to benefit from ghrelin therapy.