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[Diphenylhydantoin induces an alteration in immune system cellular functions: an in vitro study of platelet and
D Pasotti1, A Mazzone, N Antoniello
1Dipartimento di Medicina Interna e Terapia Medica, Sezione di Patologia Medica I, Università di Pavia.
Medicina (Florence, Italy)
|July 1, 1990
Abstract:
In vitro experiments were performed in order to clarify the influence of phenytoin on human granulocyte and platelet function. Therapeutic anticonvulsant concentrations of the drug significantly reduced the granulocyte aggregation produced by formyl-methionyl-leucyl-phenilalanine; phytoemoaglutinin-induced granulocyte aggregation was unaffected by phenytoin. In the same range of concentrations the drug was able to inhibit ADP-, epinephrine- and collagen-induced platelet aggregation. The possible in vivo implications of these data are discussed.