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Related Experiment Video

Updated: Jun 9, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

Neurogranin and synaptic plasticity balance.

Ling Zhong¹, Nashaat Z Gerges

¹Department of Cell Biology, Neurobiology and Anatomy; Medical College of Wisconsin; Milwaukee, WI USA.

Communicative & Integrative Biology

|August 28, 2010

Summary

Neurogranin (Ng) enhances hippocampal synaptic strength in an activity-dependent manner. This protein is crucial for long-term potentiation (LTP) and may play a role in age-related synaptic dysfunction.

Keywords:

CaMKII LTD LTP aging calcneurin calmodulin neurogranin

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Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

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Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

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Published on: March 17, 2014

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

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Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Evaluation of Synaptic Multiplicity Using Whole-cell Patch-clamp Electrophysiology

Published on: April 23, 2019

Area of Science:

Neuroscience
Molecular Biology
Synaptic Plasticity

Background:

Synaptic plasticity in the hippocampus is crucial for learning and memory.
Activity- and NMDA receptor (NMDAR)-dependent mechanisms regulate synaptic modifications.
The precise molecular pathways linking synaptic activity to postsynaptic changes remain incompletely understood.

Purpose of the Study:

To investigate the role of the postsynaptic calmodulin (CaM)-binding protein neurogranin (Ng) in hippocampal synaptic function.
To determine if Ng is involved in activity-dependent synaptic plasticity, including long-term potentiation (LTP).

Main Methods:

Electrophysiological recordings in hippocampal slices.
Investigating the effects of neurogranin (Ng) on synaptic transmission and plasticity.
Assessing NMDAR dependence and activity-dependent mechanisms.

Main Results:

Neurogranin (Ng) enhances synaptic strength in an activity- and NMDAR-dependent manner.
Ng is essential for the induction of long-term potentiation (LTP).
Ng-mediated synaptic potentiation mimics and occludes LTP, indicating a shared pathway.

Conclusions:

Neurogranin (Ng) plays a significant role in regulating hippocampal synaptic plasticity and function.
Ng's involvement in synaptic potentiation suggests potential implications for understanding aging-related deficits in synaptic plasticity.