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Related Experiment Video

Updated: Jun 9, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

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Published on: April 28, 2016

Integrating GHS into the Ghrelin System.

Johannes D Veldhuis¹, Cyril Y Bowers

¹Department of Medicine, Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, MN 55905, USA.

International Journal of Peptides

|August 28, 2010

Summary

Growth hormone secretagogues (GHSs) and their receptor, ghrelin, stimulate various physiological processes. This peptidergic system, involving ghrelin and its receptor, presents significant potential for novel drug development.

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Area of Science:

Endocrinology
Neuroscience
Pharmacology

Background:

Oligopeptide derivatives of metenkephalin were identified as growth-hormone (GH) secretagogues (GHSs) in 1977.
A specific GHS receptor, a heptahelical transmembrane receptor, was cloned in 1996, followed by the identification of its endogenous ligand, acylghrelin, in 1999.

Purpose of the Study:

To review the physiological roles and therapeutic potential of the ghrelin system.
To highlight the expression and diverse actions of ghrelin and its receptor across multiple tissues.

Main Methods:

Review of historical discoveries and scientific literature regarding GHSs and ghrelin.
Analysis of the known physiological effects mediated by the ghrelin system.

Main Results:

Ghrelin and its receptor are expressed in numerous tissues, including the brain, pituitary, stomach, and cardiovascular system.
The ghrelin system influences GH release, appetite, insulin secretion, cardiovascular function, gastric activity, and cell survival.

Conclusions:

The ghrelin system exhibits a wide range of actions, impacting key metabolic and physiological processes.
Ghrelin and its receptor represent promising therapeutic targets for drug development due to their multifaceted roles.