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Updated: Jun 9, 2026

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Published on: June 10, 2021
Dimerization of functional pyrroloindolizines for the synthesis of complex myrmicarin alkaloids
Alison E Ondrus1, H Ümit Kaniskan, Mohammad Movassaghi
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Abstract:
The union of functionalized pyrroloindolizines for the synthesis of heterodimeric products relevant to myrmicarin alkaloids is described. Design and synthesis of tricyclic substrates and new methods for their union enable the investigation of late-stage cyclopentannulation strategies. The rapid assembly of dimeric structures using unique modes of pyrroloindolizine reactivity presents a concise approach to the dimeric myrmicarins and relevant derivatives.
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