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[Juvenile arthritides]

G Horneff1

  • 1Zentrum für Allgemeine Pädiatrie und Neonatologie und Kinderrheumazentrum, Asklepios Klinik Sankt Augustin, Deutschland. g.horneff@asklepios.com

Zeitschrift Fur Rheumatologie
|August 28, 2010
PubMed

Insights

Diagnosing and treating childhood arthritis, particularly juvenile idiopathic arthritis (JIA), requires careful consideration of various conditions. This guide outlines diagnostic approaches and evidence-based therapies for JIA, including medications and biologics.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Pharmacology

Context:

  • Childhood arthritis presents complex diagnostic and therapeutic challenges.
  • A precise approach is crucial, especially for young children.
  • The differential diagnosis includes acute arthritides and chronic conditions like juvenile idiopathic arthritis (JIA).

Purpose:

  • To provide a guide for diagnosing arthritis in children.
  • To outline evidence-based therapeutic strategies for JIA.

Summary:

  • This overview covers the diagnostic spectrum of pediatric arthritis.
  • It details the evidence-based treatment of JIA, encompassing NSAIDs, corticosteroids, traditional DMARDs (sulfasalazine, methotrexate, leflunomide), TNF inhibitors (etanercept, adalimumab, infliximab), other biopharmaceuticals (anakinra, canakinumab, rilonacept), tocilizumab, and abatacept.

Impact:

  • Aids clinicians in accurate diagnosis and management of pediatric arthritis.
  • Facilitates informed therapeutic decisions for JIA based on current evidence.
  • Contributes to improved outcomes for children with inflammatory joint diseases.

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