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Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

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Neurogenic stuttering: its reticular modulation.

Subhash Bhatnagar¹, Hugh Buckingham

¹Speech Pathology and Audiology, Marquette University, Milwaukee, WI 53201-1881, USA. Subhash.bhatnagar@marquette.edu

Current Neurology and Neuroscience Reports

|August 28, 2010

Summary

This summary is machine-generated.

Neurologic studies suggest stuttering originates in the brain, involving altered activity in motor and limbic regions. Deep brain stimulation of the thalamus shows promise in improving stuttering and related symptoms.

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Area of Science:

Neuroscience
Neurology
Speech-language pathology

Background:

Emerging evidence suggests developmental and acquired stuttering have a cerebral basis.
Studies show altered brain activity in persistent developmental stuttering, including right cortical motor area activation and left perisylvian region deactivation.
Limbic (cingulate) and basal ganglia regions are also implicated in stuttering.

Observation:

This study assesses the neurology of stuttering.
It presents novel observations of deep brain stimulation (DBS) targeting the thalamus.
The intervention was applied to individuals experiencing stuttering and related speech dysfluencies.

Findings:

Compensatory brain activity in right cortical motor areas and deactivation in left perisylvian regions were observed in subjects with persistent developmental stuttering.
Treatment leading to increased speech fluency normalized compensatory brain activity, shifting activation back to the left hemisphere.
Deep brain stimulation of the thalamus demonstrated an ameliorating effect on the stuttering syndrome and associated speech dysfluency.

Implications:

These findings deepen our understanding of the neurobiological underpinnings of stuttering.
Deep brain stimulation of the thalamus presents a potential therapeutic avenue for stuttering.
Further research into brain-based interventions for speech dysfluencies is warranted.