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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

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Related Experiment Video

Updated: Jun 9, 2026

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

Genomic profiles in B cell lymphoma.

Masao Seto1

  • 1Division of Molecular Medicine, Department of Cancer Genetics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. mseto@aichi-cc.jp

International Journal of Hematology
|August 28, 2010
PubMed
Summary
This summary is machine-generated.

Chromosome translocations in B cell lymphomas create unique genome profiles. Advanced genomic technologies reveal disease-specific profiles and patient variations, explaining disease heterogeneity.

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Last Updated: Jun 9, 2026

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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

Area of Science:

  • Genomics
  • Oncology
  • Molecular Biology

Background:

  • B cell lymphomas are characterized by specific chromosome translocations that define disease entities.
  • Lymphomagenesis involves deregulated genes promoting cell proliferation and inhibiting differentiation and apoptosis.
  • Chromosome translocations alone are insufficient for tumor initiation.

Purpose of the Study:

  • To understand the molecular mechanisms of lymphoma development using new genomic technologies.
  • To analyze genome profiles and their relationship to disease characteristics and heterogeneity.

Main Methods:

  • Utilized array comparative genomic hybridization (array CGH) and expression profiling.
  • Analyzed genome profiles resulting from the human genome project.

Main Results:

  • Genome profiles are characteristic of each B cell lymphoma entity but vary significantly among patients with the same entity.
  • Recurrent genetic alterations contribute to patient-specific genome profiles.
  • These findings highlight the complexity of lymphoma development and heterogeneity.

Conclusions:

  • New genomic technologies provide a paradigm shift in understanding lymphoma molecular mechanisms.
  • The heterogeneity in genome profiles explains clinicopathological variations within the same lymphoma entity.
  • Future lymphoma research directions will focus on these advanced analyses.