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Related Experiment Videos

Optic nerve head drusen: histopathological considerations--clinical features.

L Giarelli1, G Ravalico, S Saviano

  • 1Clinica Oculistica Università, Trieste, Italy.

Metabolic, Pediatric, and Systemic Ophthalmology (New York, N.Y. : 1985)
|January 1, 1990
PubMed
Summary

Optic nerve head drusen are calcified deposits within the optic nerve head, potentially linked to axoplasmic transport and Bruch

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Area of Science:

  • Ophthalmology
  • Histopathology
  • Neuroscience

Background:

  • Optic nerve head drusen are calcified formations.
  • Pathogenesis may involve aberrant axoplasmic transport and local factors, including Bruch's membrane.
  • Spongiotic edema explains clinical findings like indistinct margins and perimetric alterations.

Observation:

  • Optic nerve head drusen are typically asymptomatic with unchanged visual acuity.
  • Threshold visual field testing quantifies defect severity and progression.
  • Retinal fluoroangiography is crucial for differentiating drusen from true papillary edema.

Findings:

  • Histopathological analysis of 18 autopsies confirmed calcified formations in optic nerve head drusen.
  • Spongiotic edema correlates with clinical signs and visual field defects.

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  • Clinical data supports the asymptomatic nature and stable visual acuity in most cases.

    • Implications:

    • Understanding the pathogenesis of optic nerve head drusen aids in diagnosis and management.
    • Accurate diagnosis using imaging techniques like fluoroangiography is essential.
    • Monitoring visual field defects is key to tracking disease progression.