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Updated: Jun 9, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Published on: October 29, 2013

Amidated pectin based hydrogels: synthesis, characterization and cytocompatibility study.

R K Mishra¹, J P Singhal, M Datt

¹Department of Polymer Science, Bundelkhand University, Jhansi - India.

Journal of Applied Biomaterials & Biomechanics : JABB

|August 28, 2010

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Chemically modified pectin with diethanolamine (DA) forms novel hydrogels. These diethanolamine modified pectin (DAMP) hydrogels exhibit enhanced crystallinity and good hemocompatibility, suitable for drug delivery applications.

Area of Science:

Materials Science
Biomaterials Engineering
Polymer Chemistry

Background:

Pectin, a natural polysaccharide, is a promising biomaterial for hydrogel development.
Chemical modification is essential to enhance pectin's properties for advanced applications.
Developing novel hydrogels with improved characteristics is crucial for biomedical uses.

Purpose of the Study:

To synthesize and characterize diethanolamine modified pectin (DAMP) hydrogels.
To evaluate the structural, physical, and biological properties of the developed hydrogels.
To assess the potential of DAMP hydrogels for drug delivery applications.

Main Methods:

Pectin was chemically modified with diethanolamine (DA) at varying concentrations.
Hydrogels were prepared using glutaraldehyde (GA) crosslinking.

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Characterization involved FTIR, elemental analysis, XRD, swelling, hemocompatibility, and cytocompatibility tests.

Drug release studies were conducted using a Franz's diffusion cell.

Main Results:

FTIR confirmed the presence of amide bands, indicating successful modification.
XRD showed increased crystallinity in DAMP hydrogels compared to native pectin.
Hydrogels demonstrated significant swelling capacity and good hemocompatibility with human blood.
Cytocompatibility studies showed no adverse effects on B-16 melanoma cells.
Drug release studies indicated potential for controlled release applications.

Conclusions:

Diethanolamine modification successfully produced pectin-based hydrogels (DAMP) with enhanced properties.
The DAMP hydrogels exhibit favorable characteristics for biomedical applications, including drug delivery.
These findings highlight the potential of modified pectin as a versatile biomaterial.