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Updated: Jun 9, 2026

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
Published on: February 9, 2019
Parametric imaging of cancer with optical coherence tomography
Robert A McLaughlin1, Loretta Scolaro, Peter Robbins
1University of Western Australia, School of Electrical, Electronic and Computer Engineering, Crawley, West Australia, Australia. robertm@ee.uwa.edu.au
Abstract:
We present a parametric optical coherence tomography (OCT) technique to improve contrast between malignant and healthy non-neoplastic tissue. The technique incorporates a fully automated method to extract tissue attenuation characteristics. Results are represented visually as a parametric en face image, where the parameter used for contrast is indicative of the relative optical attenuation coefficient of the tissue. We present the first parametric OCT images of human lymph nodes containing malignant cells, and demonstrate improved tissue contrast over en face OCT images.
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