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Updated: Jun 9, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Cholesteryl ester transfer protein Taq1B polymorphism in an angiographically assessed Turkish population: no effects
Sevda Tanrikulu-Kucuk1, Evin Ademoglu, Figen Gurdol
1Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. sevdat@istanbul.edu.tr
Background:
Taq1B polymorphism of cholesteryl ester transfer protein (CETP) is believed to associate with high-density lipoprotein-cholesterol (HDL-C) levels and may alter the susceptibility to atherosclerosis.
Aim Of The Study:
This study investigated the effects of Taq1B polymorphism on HDL-C and coronary artery disease (CAD) risk in angiographically defined CAD patients.
Methods:
One hundred thirty-five CAD patients and 112 healthy controls were screened for the CETP Taq1B genotype and plasma lipids.
Results:
The genotype frequency of CAD patients and controls were similar. The HDL-C levels of all genotypes in the CAD group were significantly lower than the corresponding controls. Smoking and plasma triglycerides were the predictors of the HDL-C level in B1B1 bearers, whereas the subjects with a polymorphic B2 allele were affected by smoking and sex.
Conclusion:
CETP Taq1B polymorphism neither plays a role in determining HDL-C levels nor is a useful predictor of the risk of CAD.
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