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Nosocomial outbreak of Crimean-Congo haemorrhagic fever

H R Naderi1, M R Sarvghad, A Bojdy

  • 1Department of Infectious Diseases, Imam Reza General Hospital, School of Medicine, Mashhad University of Medical Sciences, Iran.

Epidemiology and Infection
|August 31, 2010
PubMed

Insights

A Crimean-Congo hemorrhagic fever (CCHF) outbreak in Iran affected six patients, including healthcare workers, highlighting transmission risks. Early diagnosis and ribavirin treatment are crucial for managing this viral hemorrhagic fever.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral disease.
  • Nosocomial outbreaks pose significant risks in healthcare settings, particularly in endemic regions.
  • Understanding transmission dynamics is critical for effective control.

Purpose of the Study:

  • To report a nosocomial outbreak of CCHF in Mashhad, Iran.
  • To investigate the transmission routes and identify risk factors.
  • To emphasize the importance of early diagnosis and management.

Main Methods:

  • Retrospective case analysis of a CCHF outbreak in Ghaem Hospital.
  • Diagnostic confirmation using reverse transcription polymerase chain reaction (RT-PCR).
  • Clinical management with ribavirin.

Main Results:

  • Six patients were affected, including four healthcare workers, linked to an index case.
  • Transmission occurred via percutaneous exposure and direct contact with contaminated materials.
  • Four survivors confirmed virologically; two fatal cases lacked confirmation.
  • Ribavirin was administered to patients.

Conclusions:

  • Healthcare-associated transmission of CCHF is a significant concern.
  • Prompt diagnosis and isolation are essential for controlling CCHF outbreaks.
  • Ribavirin should be considered in treating probable CCHF cases in endemic areas.

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