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Related Experiment Videos

[Hypertensive emergency during large vessel surgery].

C Pagani1, S Selva, G Meloni

  • 1II Cattedra di Anestesia e Rianimazione, Università degli Studi di Milano.

Minerva Cardioangiologica
|July 1, 1990
PubMed
Summary

Urapidil effectively manages intraoperative hypertensive crises with both rapid bolus delivery and sustained continuous infusion. This alpha-blocking agent demonstrates significant hypotensive function and a favorable safety profile.

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Area of Science:

  • Anesthesiology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Intraoperative hypertensive crises pose significant risks during surgery.
  • Effective management requires agents with rapid onset and sustained action.
  • Alpha-blocking agents are crucial for controlling blood pressure fluctuations.

Purpose of the Study:

  • To evaluate the efficacy of urapidil, an alpha-blocking agent, in managing intraoperative hypertensive crises.
  • To compare the hypotensive effects of urapidil administered via bolus injection versus continuous infusion.
  • To assess the safety and side-effect profile of urapidil in surgical settings.

Main Methods:

  • A study evaluating urapidil's effectiveness during intraoperative hypertensive crises.
  • Administration of urapidil in both bolus and continuous infusion forms.

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  • Monitoring of systolic, diastolic, and mean arterial pressure, along with heart rate.
  • Statistical analysis of collected hemodynamic data.

    • Main Results:

    • Urapidil demonstrated a rapid hypotensive effect when administered as a bolus.
    • Continuous infusion of urapidil provided a long-lasting blood pressure-lowering effect.
    • Hemodynamic parameters including systolic, diastolic, and mean pressure, and heart rate were significantly impacted.

    Conclusions:

    • Urapidil exhibits both rapid and sustained hypotensive efficacy.
    • The agent was effective in managing intraoperative hypertensive crises.
    • No significant side-effects were observed, suggesting urapidil as a potentially optimal choice for intraoperative hypertension.