Related Experiment Video
Updated: Jun 9, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
Published on: November 26, 2015
Botox transient treatment of tinnitus due to stapedius myoclonus: case report
Hai-Bin Liu1, Jing-Ping Fan, Shun-Zhang Lin
1Department of Otolaryngology-Head & Neck Surgery, ChangZheng Hospital, Second Military Medical University, Fengyang Road 415, Huangpu District, Shanghai, China.
Object:
To explore the feasibility of using botulinum toxin type A (BTXA) to treat tinnitus due to stapedius myoclonus.
Method:
A piece of gelfoam containing BTXA (25 U/ml) was placed, through a perforation in tympanic membrane, into the middle ear cavity of a patient suffering from tinnitus due to stapedius myoclonus.
Results:
The tinnitus disappeared on the second day after the BTXA treatment. The patient was free of symptoms during a 3-month follow-up period. Tinnitus reappeared at 4 months, and disappeared after second BTXA local treatment.
Conclusion:
Local BTXA treatment may be considered as a treatment for tinnitus caused by stapedius myoclonus.

