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Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

Transient oncogenes.

G Lenz1

  • 1Department of Biophysics and Center of Biotechnology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. lenz@ufrgs.br

Medical Hypotheses
|August 31, 2010
PubMed
Summary
This summary is machine-generated.

Cancer cells may rely on transient oncogenes, like Yamanaka factors, for formation by altering cell differentiation. Targeting these overlooked factors could revolutionize cancer treatment and prevention.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer arises from genetic alterations activating oncogenes and inactivating tumor suppressor genes.
  • Cancer cells exhibit addiction to oncogenes, making their inhibition a therapeutic strategy.
  • Traditional oncogenes (e.g., RasV12) sustain pro-survival and proliferation signals.

Purpose of the Study:

  • To propose the hypothesis that oncogenes can be transiently activated.
  • To investigate the role of transient oncogene activation in cancer formation by affecting cell differentiation.
  • To highlight the potential of "transient oncogenes" as a new class of targets in cancer research.

Main Methods:

  • Review and synthesis of published evidence supporting the transient oncogene hypothesis.
  • Analysis of transcription factors, such as Yamanaka factors, as potential transient oncogenes.
  • Discussion of the implications for genomic and proteomic analyses.

Main Results:

  • Transient oncogene activation, particularly by factors influencing cell differentiation, is proposed as crucial for cancer development.
  • Yamanaka factors are suggested as candidates for transient oncogenes due to their cell-reprogramming capabilities.
  • Transient oncogenes are likely missed in standard genomic/proteomic analyses due to their short-lived nature.

Conclusions:

  • Transient oncogenes represent a novel class of oncogenic drivers potentially critical in cancer biology.
  • Identifying and targeting these transient factors could offer new avenues for cancer treatment and prevention.
  • Further research into transient oncogenes may significantly impact our understanding and management of cancer.