Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated Germline and Somatic Molecular Profiling to Detect Cancer Predisposition Has a High Clinical Impact in Poor-Prognosis Pediatric Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Author Correction: Returning raw genomic data to research participants in a pediatric cancer precision medicine trial.

NPJ genomic medicine·2025
Same author

Returning raw genomic data to research participants in a pediatric cancer precision medicine trial.

NPJ genomic medicine·2025
Same author

Genetic counseling workforce diversity, inclusion, and capacity in Australia and New Zealand.

Genetics in medicine open·2024
Same author

Genetic counsellors: facilitating the integration of genomics into health care.

The Medical journal of Australia·2024
Same author

Parents' and patients' perspectives, experiences, and preferences for germline genetic or genomic testing of children with cancer: A systematic review.

Genetics in medicine : official journal of the American College of Medical Genetics·2024

Related Experiment Video

Updated: Jun 9, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Transcriptome profiling in neurodegenerative disease.

Eliza Courtney1, Shan Kornfeld, Karolina Janitz

  • 1School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia.

Journal of Neuroscience Methods
|August 31, 2010
PubMed
Summary

Gene expression and splicing changes are key to understanding neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's. Analyzing these patterns aids in discovering new therapeutic drugs.

More Related Videos

Purification of Transcripts and Metabolites from Drosophila Heads
12:49

Purification of Transcripts and Metabolites from Drosophila Heads

Published on: March 15, 2013

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Related Experiment Videos

Last Updated: Jun 9, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Purification of Transcripts and Metabolites from Drosophila Heads
12:49

Purification of Transcripts and Metabolites from Drosophila Heads

Published on: March 15, 2013

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
07:08

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Gene expression and splicing alterations are critical in the development and progression of complex neurodegenerative diseases.
  • Studying these molecular changes offers insights into disease mechanisms and potential drug targets.
  • Advancements in technologies like RNA-sequencing are rapidly expanding our understanding of neurodegenerative disease pathogenesis.

Purpose of the Study:

  • To review technologies for analyzing gene expression and splicing patterns.
  • To discuss the literature concerning these patterns in Alzheimer's disease, Parkinson's disease, and Huntington's disease.

Main Methods:

  • Review of array technologies for gene expression analysis.
  • Review of RNA-sequencing (RNA-seq) techniques for gene expression and splicing analysis.
  • Literature review focused on Alzheimer's, Parkinson's, and Huntington's disease.

Main Results:

  • Gene expression and splicing analyses are vital for understanding neurodegenerative disease.
  • Technological advancements have significantly improved the ability to study these molecular changes.
  • The reviewed literature highlights the role of altered gene expression in Alzheimer's, Parkinson's, and Huntington's disease.

Conclusions:

  • Gene expression and splicing pattern analysis are crucial for neurodegenerative disease research.
  • These analyses can identify molecular pathogenesis mechanisms and potential therapeutic targets.
  • Further research utilizing advanced technologies will continue to illuminate neurodegenerative disease pathways.