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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Jun 9, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Premenstrual asthma and atopy markers.

Antonio Pereira-Vega1, José L Sánchez, José A Maldonado

  • 1Pneumology Section, Hospital Juan Ramón Jiménez de Huelva, Department of Nursing, University of Huelva, Huelva, Spain. apv01h@saludalia.com

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|August 31, 2010
PubMed
Summary

Premenstrual asthma (PMA) in women is linked to higher total immunoglobulin E (IgE) levels, but not specific allergens. Atopy influences how PMA clinically manifests in reproductive-aged women.

More Related Videos

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: Jun 9, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Allergy and Immunology
  • Pulmonology
  • Women's Health

Background:

  • The relationship between atopy and premenstrual asthma (PMA) exacerbations is not well understood.
  • Investigating atopy markers in women with premenstrual asthma is crucial for understanding asthma management.

Purpose of the Study:

  • To determine the association between atopy markers, including total IgE, Phadiatop, and specific IgE, and premenstrual asthma (PMA).
  • To analyze how atopy influences the clinical presentation of premenstrual asthma in women of reproductive age.

Main Methods:

  • Asthmatic women of reproductive age were assessed for PMA based on respiratory symptoms and peak flow monitoring throughout the menstrual cycle.
  • Asthma severity was graded using the Global Initiative for Asthma scale.
  • Blood tests measured total IgE, Phadiatop (allergen screening), and specific IgE levels.

Main Results:

  • Of 59 asthmatic women, 31 (53%) had PMA.
  • Significantly higher total IgE levels (>100 kU/L) were observed in women with PMA (84%) compared to those without (43%) (P=.001).
  • No significant association was found between PMA and Phadiatop or specific IgE levels.

Conclusions:

  • Premenstrual asthma (PMA) appears strongly correlated with elevated total IgE levels.
  • Specific allergens do not show a clear link to PMA, suggesting atopy's role is mediated by general IgE levels.
  • Atopy significantly impacts the clinical manifestations of premenstrual asthma in women of reproductive age.