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[Cholestasis in liver transplantation: incidence and diagnostic significance]
I Pecorella1, A Ciardi, S Rahimi
1Dipartimento di biopatologia umana dell'Università La Sapienza di Roma.
Pathologica
|September 1, 1990
Abstract:
Cholestasis is frequently encountered in human liver transplants. In a series of 82 liver fine-needle aspiration biopsies performed in 20 grafted patients, the incidence rate of cholestasis was 55%. Cholestasis may predominantly be localized in the hepatocyte cytoplasm, or in the biliary tree or in both sites. In our cases it was most frequently associated with acute rejection (53%), followed by preservation injuries (29%) and ciclosporin toxicity (12%), respectively. The severity and the chronologic distribution of cholestatic episodes seem to vary according to the other associated pathologic conditions.