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Updated: Jun 9, 2026

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

The acoustic scatter from single biSphere microbubbles.

D H Thomas1, M B Butler, A Dermitzakis

  • 1Medical Physics and Medical Engineering, University of Edinburgh, Edinburgh, UK. d.h.thomas@ed.ac.uk

Ultrasound in Medicine & Biology
|August 31, 2010
PubMed
Summary
This summary is machine-generated.

Acoustic signals from microbubbles reveal shell disruption and gas release mechanisms, crucial for optimizing ultrasound imaging and therapeutic applications.

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Area of Science:

  • Biomedical acoustics
  • Ultrasound imaging
  • Microbubble contrast agents

Background:

  • Microbubble contrast agents are widely used in medical imaging.
  • Understanding microbubble behavior under acoustic stimulation is key to enhancing imaging resolution and therapeutic efficacy.
  • Previous studies have focused on optical observations, limiting insights into acoustic-induced mechanisms.

Purpose of the Study:

  • To investigate the acoustic responses of single microbubbles.
  • To elucidate the mechanisms of acoustic scatter from microbubbles.
  • To provide data for optimizing ultrasound pulse parameters for improved diagnostic and therapeutic applications.

Main Methods:

  • Acquisition of acoustic signals from single polylactide-shelled and albumin-coated biSphere™ microbubbles.
  • Varying incident frequencies and acoustic pressures.
  • Analysis of echo durations and characteristics.

Main Results:

  • Observed varied echo durations based on incident parameters.
  • Detected partial echoes shorter than the incident pulse duration at low frequencies and high amplitudes.
  • Inferred gas release from microbubbles, suggesting shell disruption or leakage from defects.

Conclusions:

  • Acoustic scatter from hard-shelled microbubbles may involve shell disruption and gas release.
  • Gas leakage from defected shell sites is a potential, previously unobserved mechanism.
  • Optimizing acoustic pulse parameters based on these findings can enhance ultrasound diagnostic and therapeutic techniques.