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Pyoderma gangrenosum in childhood leukemia.
A Hayani1, C P Steuber, D H Mahoney
1Department of Pediatrics, Texas Children's Hospital, Houston.
Pediatric Dermatology
|December 1, 1990
Summary
Pyoderma gangrenosum (PG) can occur in children with acute myelogenous leukemia (AML). This case shows PG lesions responded to prednisone treatment, even with active leukemia.
Area of Science:
- Dermatology
- Pediatric Oncology
Background:
- Pyoderma gangrenosum (PG) is a rare, inflammatory neutrophilic dermatosis.
- Acute myelogenous leukemia (AML) is a cancer of the myeloid line of blood cells.
Observation:
- A 14-year-old boy with AML developed PG lesions.
- The onset of PG lesions coincided with AML relapse.
Findings:
- The patient's PG lesions showed a dramatic response to oral prednisone treatment.
- Leukemia persisted despite the positive response of skin lesions to prednisone.
Implications:
- Pyoderma gangrenosum should be considered in the differential diagnosis of cutaneous eruptions in pediatric leukemia patients.
- Early recognition and management of PG may improve patient outcomes during leukemia treatment.