[Vitamin E and malondialdehyde in the blood serum of thyrotoxicosis patients]

The concentrations of vitamin E and malonic dialdehyde (MDA) were investigated in the blood serum of 146 patients with diffuse goiter of various degree of severity and in 35 controls with diffuse and nodular goiter without thyroid dysfunction. Vitamin E and MDA concentrations in patients with mild thyrotoxicosis did not differ from that in the controls. Vitamin E concentrations in patients with moderate and severe types of thyrotoxicosis were notably decreased and MDA concentration was elevated. The data on decreased vitamin E concentrations and increased MDA concentrations indicated vitamin E insufficiency in these patients. This fat-soluble antioxidant is recommended for multimodality therapy of thyrotoxicosis.