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Bone marrow and circulating stem/progenitor cells for regenerative cardiovascular therapy

Mohamad Amer Alaiti1, Masakazu Ishikawa, Marco A Costa

  • 1Division of Cardiovascular Medicine, Harrington-McLaughlin Heart and Vascular Institute, University Hospitals, Case Western Reserve University, Cleveland, OH 44106-5038, USA. Marco.Costa@UHhospitals.org

Translational Research : the Journal of Laboratory and Clinical Medicine
|August 31, 2010
PubMed

Insights

Regenerative medicine using stem cells offers potential for cardiovascular disease treatment. This review examines the benefits and drawbacks of stem cell therapy based on animal and human studies.

Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Cardiovascular disease remains a primary cause of mortality and morbidity globally.
  • Current treatments aim to reduce cardiovascular disease burden.
  • Regenerative medicine and cell-based therapies are emerging as promising therapeutic strategies.

Purpose of the Study:

  • To review the potential of stem and endothelial progenitor cells for cardiovascular regeneration.
  • To highlight the advantages and limitations of stem cell-based cardiovascular therapy.
  • To synthesize findings from preclinical animal studies and clinical trials.

Main Methods:

  • Literature review of studies on stem and endothelial progenitor cells in cardiovascular regeneration.
  • Analysis of data from animal models of cardiovascular disease.
  • Evaluation of outcomes from human clinical trials investigating cell-based therapies.

Main Results:

  • Stem and endothelial progenitor cells show promise for cardiovascular repair.
  • Various stem cell types demonstrate regenerative potential in preclinical models.
  • Clinical trial results indicate both feasibility and challenges in translating cell therapy.

Conclusions:

  • Stem cell therapy is a viable area of investigation for cardiovascular disease.
  • Further research is needed to optimize cell sources, delivery, and efficacy.
  • Translating preclinical findings into effective clinical treatments requires careful consideration of limitations.

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