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Updated: Jun 9, 2026

Establishment of an Embryo Implantation Model In Vitro
Published on: June 21, 2024
GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles
Miki Bloch1, Foad Azem, Inbar Aharonov
1Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. mikib@tasmc.health.gov.il
Abstract:
To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters.
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