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Related Concept Videos

Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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What are Cells?01:15

What are Cells?

Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium, or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
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What are Cells?01:07

What are Cells?

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Studying the Cytoskeleton

The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...

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Updated: Jun 9, 2026

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
08:47

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

Published on: July 5, 2019

Cellular structural biology.

Yutaka Ito1, Philipp Selenko

  • 1Tokyo Metropolitan University, Department of Chemistry, Minami-Osawa, Hachioji, Tokyo 192-0397, Japan.

Current Opinion in Structural Biology
|August 31, 2010
PubMed
Summary
This summary is machine-generated.

In-cell NMR spectroscopy offers a novel way to study protein structures within live cells. This technique provides atomic-level insights into biomolecular function and conformation in native cellular environments.

More Related Videos

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
13:43

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

Micro-scale Engineering for Cell Biology
04:42

Micro-scale Engineering for Cell Biology

Published on: October 1, 2007

Related Experiment Videos

Last Updated: Jun 9, 2026

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
08:47

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans

Published on: July 5, 2019

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
13:43

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

Micro-scale Engineering for Cell Biology
04:42

Micro-scale Engineering for Cell Biology

Published on: October 1, 2007

Area of Science:

  • Biophysics
  • Structural Biology
  • Cell Biology

Background:

  • The intracellular environment is complex, yet tools for analyzing protein structures within cells are limited.
  • Understanding biomolecular behavior requires studying proteins in their native cellular context.

Purpose of the Study:

  • To review recent advancements in in-cell NMR spectroscopy.
  • To highlight the potential of in-cell NMR for studying complex biological processes.
  • To explore future applications of in-cell NMR in both prokaryotic and eukaryotic cells.

Main Methods:

  • In-cell NMR spectroscopy is presented as a key biophysical technique.
  • The review discusses developments enabling atomic-level analysis of biomolecules inside live cells.

Main Results:

  • In-cell NMR spectroscopy allows investigation of protein conformation and function.
  • The technique provides structural insights within native cellular environments.

Conclusions:

  • In-cell NMR spectroscopy is a powerful tool for cellular studies.
  • This technique facilitates structural analysis of biomolecules in their native state, advancing our understanding of cellular processes.