Cellular structural biology
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Updated: Jun 9, 2026

Quantitative Approaches for Studying Cellular Structures and Organelle Morphology in Caenorhabditis elegans
Published on: July 5, 2019
1Tokyo Metropolitan University, Department of Chemistry, Minami-Osawa, Hachioji, Tokyo 192-0397, Japan.
Abstract:
While we appreciate the complexity of the intracellular environment as a general property of every living organism, we collectively lack the appropriate tools to analyze protein structures in a cellular context. In-cell NMR spectroscopy represents a novel biophysical tool to investigate the conformational and functional characteristics of biomolecules at the atomic level inside live cells. Here, we review recent in-cell NMR developments and provide an outlook towards future applications in prokaryotic and eukaryotic cells. We hope to thereby emphasize the usefulness of in-cell NMR techniques for cellular studies of complex biological processes and for structural analyses in native environments.
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