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Updated: Jun 9, 2026
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iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
Published on: April 30, 2011
ncRNAimprint: a comprehensive database of mammalian imprinted noncoding RNAs
Ying Zhang1, Dao-Gang Guan, Jian-Hua Yang
1State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.
RNA (New York, N.Y.)
|August 31, 2010
Summary
Imprinted noncoding RNAs (ncRNAs) are crucial in mammals and linked to human diseases. The ncRNAimprint database offers a centralized resource for these ncRNAs, aiding research and discovery.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Imprinted noncoding RNAs (ncRNAs) are mono-allelically expressed in mammals, playing key roles in genomic imprinting.
- Abnormalities in imprinted ncRNAs are increasingly linked to various human diseases.
- Existing knowledge on imprinted ncRNAs is fragmented across numerous studies.
Purpose of the Study:
- To establish ncRNAimprint, a comprehensive database for mammalian imprinted ncRNAs.
- To consolidate scattered information on imprinted ncRNAs, their functions, and associated diseases.
- To provide a valuable resource for researchers studying genomic imprinting and ncRNA biology.
Main Methods:
- Compiled and annotated a catalog of diverse imprinted ncRNAs (snoRNAs, microRNAs, piRNAs, etc.).
- Manually curated data on imprinted ncRNA-related diseases, imprinting control regions (ICRs), and imprinted regions.
- Integrated small RNA deep sequencing data for novel ncRNA detection and expression analysis.
Main Results:
- Developed ncRNAimprint, a centralized database for mammalian imprinted ncRNAs.
- The database includes detailed annotations, disease associations, ICRs, and imprinted regions.
- Incorporated search functionalities and graphical browsers for data retrieval and visualization.
Conclusions:
- ncRNAimprint serves as a comprehensive and accessible resource for mammalian imprinted ncRNAs.
- The database facilitates research on the function, regulation, and disease relevance of imprinted ncRNAs.
- Provides essential data for identifying novel imprinted ncRNAs and understanding their expression patterns.
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