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Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

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Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry

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Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype.

Hélène Lemieux¹, Edwin J Vazquez, Hisashi Fujioka

¹Center for Mitochondrial Disease, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|August 31, 2010

Summary

This summary is machine-generated.

Aging significantly impairs cardiac mitochondrial function, especially in shorter-lived Fischer 344 rats. Longer-lived Brown Norway rats and hybrids show preserved mitochondrial function, highlighting mitochondria

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Area of Science:

Gerontology
Cardiovascular Biology
Mitochondrial Medicine

Background:

Cardiac aging is associated with mitochondrial dysfunction.
Rat strains exhibit varying longevity and aging phenotypes.

Purpose of the Study:

To investigate the relationship between aging, cardiac mitochondrial function, and longevity in different rat strains.
To compare the impact of aging on mitochondrial respiration in Fischer 344, Brown Norway, and hybrid F344×BN rats.

Main Methods:

Measurement of cardiac mitochondrial oxidation and respiration in permeabilized fibers from young and old rats.
Assay of citrate synthase activity to determine mitochondrial content.
Comparison of mitochondrial function across three distinct rat strains with differing lifespans.

Main Results:

Fischer 344 rats showed a significant ~45% decrease in coupled mitochondrial oxidation with aging.
Brown Norway rats exhibited a non-significant 15%-18% loss in mitochondrial respiration.
Hybrid F344×BN rats demonstrated preserved cardiac mitochondrial function during aging.

Conclusions:

Cardiac mitochondrial dysfunction is correlated with reduced longevity across rat strains.
Mitochondria play a crucial role in the aging process of the heart.
Preserved mitochondrial function in hybrids may contribute to their resistance to aging.