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Morphine conditioned place preference in the hamster.

P Schnur1, J Morrell

  • 1Department of Psychology, University of Southern Colorado, Pueblo 81001-4901.

Pharmacology, Biochemistry, and Behavior
|October 1, 1990
PubMed
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High doses of morphine induce conditioned place preference in hamsters, unlike in rats. Naloxone blocks this effect and causes aversion, indicating morphine

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Opioid drugs, such as morphine, are known to produce rewarding effects.
  • Conditioned place preference (CPP) is a behavioral paradigm used to assess the rewarding properties of drugs.
  • Previous research has established CPP in various species, but data in hamsters is limited.

Purpose of the Study:

  • To investigate the dose-dependent effects of morphine on conditioned place preference in hamsters.
  • To examine the role of opioid receptors in morphine-induced CPP using naloxone.
  • To compare CPP findings in hamsters with those reported in rats.

Main Methods:

  • Two experiments were conducted using male hamsters.
  • Experiment 1: Hamsters received either morphine (15 mg/kg) or saline, followed by testing in a two-compartment chamber to assess place preference. Naloxone (0.4 mg/kg) was used to block morphine effects.

Related Experiment Videos

  • Experiment 2: Hamsters were conditioned with four different doses of morphine (0, 2.5, 5, and 15 mg/kg) to determine the effective dose for CPP.

    • Main Results:

    • A significant conditioned place preference was observed in hamsters receiving a 15 mg/kg dose of morphine.
    • Naloxone (0.4 mg/kg) successfully blocked the development of morphine-induced CPP and induced a conditioned place aversion.
    • Only the highest dose of morphine (15 mg/kg) produced a significant place preference, while lower doses did not.

    Conclusions:

    • A relatively high dose of morphine is required to establish a conditioned place preference in hamsters.
    • Opioid receptor antagonism by naloxone prevents morphine CPP and induces aversion, supporting the involvement of opioid pathways.
    • These findings highlight species-specific differences in the rewarding effects of morphine, with hamsters requiring higher doses compared to rats.