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[New derivatives of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepine-11-ones with anticholinergic activity]
C Rüger1, H Röhnert, D Lohmann
1Geschäftsbereich Forschung und Entwicklung Arzneimittelwerk Dresden GmbH.
Die Pharmazie
|July 1, 1990
Abstract:
Starting from 2-aminobenzoic acid and correspondingly substituted 2-chloronitrobenzenes, 5-substituted-aminoacyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin -11- one derivatives with a differently high activity on ulcers were prepared. 8-Chloro-5,10-dihydro-5-[bis(2-hydroxyethyl)a-minoacetyl]-11H- dibenzo[b,e][1,4]diazepin-11-one hydrochloride (AWD 26-06) was selected for further clinical evaluation.