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Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
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Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

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Complete genome sequence of Mycoplasma hyorhinis strain HUB-1

Wei Liu1, Liurong Fang, Sha Li

  • 1Division of Animal Infectious Diseases, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.

Journal of Bacteriology
|August 31, 2010
PubMed

Insights

Mycoplasma hyorhinis, a swine pathogen, frequently infects lab cell lines and may cause cancer. This study presents the complete genome sequence of the M. hyorhinis HUB-1 strain.

Area of Science:

  • Microbiology
  • Genomics
  • Cell Biology

Background:

  • Mycoplasma hyorhinis is recognized as a swine pathogen.
  • This bacterium is frequently detected in laboratory cell cultures.
  • Emerging evidence links chronic M. hyorhinis infections to oncogenic transformation.

Purpose of the Study:

  • To present the complete genome sequence of Mycoplasma hyorhinis strain HUB-1.
  • To provide a genomic resource for understanding M. hyorhinis biology and pathogenesis.

Main Methods:

  • Whole-genome sequencing of Mycoplasma hyorhinis strain HUB-1.
  • Bioinformatic analysis of the genome sequence.

Main Results:

  • The complete genome sequence of M. hyorhinis strain HUB-1 has been determined.
  • The genome provides insights into the genetic makeup of this commonly encountered cell line contaminant.

Conclusions:

  • The availability of the M. hyorhinis HUB-1 genome sequence facilitates further research into its role in cell culture and potential oncogenic mechanisms.

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