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Histopathological changes of cornea in long-term sympathetic ophthalmitis
V Shankar1, F Roberts, K Ramaesh
1Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, United Kingdom. vashankar73@yahoo.co.uk
Purpose:
To report the histopathological changes occurring in the cornea in sympathetic ophthalmitis.
Methods:
Observational case series of 3 patients with sympathetic ophthalmitis who were treated with penetrating keratoplasty. We report the histopathological features of the cornea.
Results:
In all 3 cases, the epithelium was edematous and bullous with extensive loss of the Bowman layer and calcification of the superficial stroma in all the 3 eyes. The deep stroma was unremarkable in appearance. Descemet membrane showed thickening in 2 of the corneas with nodular excrescences and folds noted in 1 of the specimens. The endothelium was attenuated with some residual cells containing pigment granules in 1 case.
Conclusions:
Endothelial loss and development of bullous keratopathy associated with band keratopathy are predominate histopathological features of the cornea. These changes are nonspecific and reflect a chronic anterior uveitis.
