Potential pathomechanisms of ADHD based on neurometabolite changes
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Updated: Jun 9, 2026

Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol
Published on: April 1, 2018
Veronika Husarova1, Igor Ondrejka, Ingrid Tonhajzerova
1Clinic of Psychiatry, Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. nika.husarova@gmail.com
Abstract:
Attention deficit hyperactivity disorder (ADHD) is a most common psychiatric disorder in the childhood. The exact pathomechanisms related to ADHD core symptoms--hyperactivity, impulsivity and inattention--are still unclear. The developmental dysfunction of cortical-striatal-thalamic-cortical network combined with the dysregulation of catecholamine neurotransmitters could be responsible for symptoms of the disorder. Magnetic resonance spectroscopy is a method which allows a partial view on molecular mechanisms of biochemical and metabolic processes in human brain by in vivo measurement. We address the hypothesis of a potential pathomechanisms associated with ADHD symptoms which is based on the studies concerning magnetic resonance spectroscopy method and ADHD.
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