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Pheno- and genotypic characteristics of human non-Hodgkin lymphoma xenografts
L Kopper1, A Bánkfalvi, R Mihalik
1Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
Acta Histochemica. Supplementband
|January 1, 1990
Abstract:
The three human non-Hodgkin lymphoma xenografts with different morphological appearance (lymphoblastic, centroblastic, centrocytic) had many common pheno- and genotypic features positivity of B-cell markers, 14q+ chromosomal abnormality, etc.). Furthermore, two lines (HT 58 and 130) expressed lambda light chain monoclonally. The third line (HT 117) showed bigenotypic rearrangement of light genes. A set of new anti-proteoglycan markers, especially anti-chondroitin sulfate mAbs made possible to individualize the xenografts.