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[Chagas cardiomyopathy: prognosis in clinical and hemodynamic profile C]

Juliano Cardoso1, Milena Novaes, Marcelo Ochiai

  • 1InCor Hospital de Cotoxó, HCFMUSP, São Paulo, SP, Brasil. julianonc@cardiol.br

Arquivos Brasileiros De Cardiologia
|August 31, 2010
PubMed

Insights

Patients with advanced heart failure (HF) and Chagas disease have a significantly worse prognosis. Chagas cardiomyopathy is an independent predictor of mortality in decompensated heart failure patients with profile C.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Context:

  • Patients with heart failure (HF) presenting with poor perfusion and congestion (clinical-hemodynamic profile C) exhibit the worst prognosis in decompensated HF.
  • Etiology of cardiomyopathy significantly impacts outcomes in advanced HF, yet remains understudied.

Purpose:

  • To evaluate the prognosis of patients admitted with clinical-hemodynamic profile C.
  • To determine the influence of cardiomyopathy etiology, specifically Chagas disease, on patient outcomes in advanced HF.

Summary:

  • A cohort study included 100 patients with advanced HF (LVEF < 45.0%, functional class IV, profile C), divided into chagasic (Ch) and non-chagasic (NCh) groups.
  • Chagasic patients were younger and had lower systolic blood pressure. Over 25 months, mortality was 66.7% for Ch versus 37.3% for NCh (p=0.019).
  • Chagas disease was identified as an independent predictor of poor prognosis (RR 2.75).

Impact:

  • This study highlights Chagas disease as a critical factor influencing mortality in advanced heart failure.
  • Findings underscore the need for considering Chagas etiology in risk stratification and management of HF patients.
Abstract

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