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10:28
Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
[Cocaine base paste: experience from the Montevideo Poison Control Center]
Antonio Pascale1, Alba Negrin, Amalia Laborde
1Departamento de Toxicología, Centro de Información y Asesoramiento Toxicológico, Hospital de Clínicas, Montevideo, Uruguay. dr_antoniopascale@yahoo.com
Adicciones
|August 31, 2010
Summary
Cocaine base paste (CBP) abuse primarily affects young males in Uruguay, presenting with neuropsychiatric, cardiovascular, and respiratory symptoms. High rates of overdose and suicide attempts highlight the severe clinical impact of CBP use.
Area of Science:
- Clinical Toxicology
- Substance Abuse Research
- Public Health
Context:
- Cocaine base paste (CBP) is a prevalent form of cocaine in Uruguay.
- Understanding the clinical profile of CBP abusers is crucial for targeted interventions.
- Previous research has not fully elucidated the specific clinical characteristics of CBP abuse in this region.
Purpose:
- To determine the primary clinical characteristics of individuals abusing cocaine base paste (CBP).
- To analyze consultation data related to CBP use at a major poison control center.
Summary:
- A retrospective study of 113 consultations at the Montevideo Poison Control Center (2004-2005) identified young males (avg. age 22) as the primary demographic for CBP abuse.
- Consultations were mainly for drug overdose (77%), suicide attempts (16.8%), and cessation of use (6.2%).
- Commonly observed symptoms included neuropsychiatric, cardiovascular, and respiratory issues, often exacerbated by concurrent use of alcohol, marijuana, or benzodiazepines.
Impact:
- Findings underscore the significant public health burden of CBP abuse, particularly its association with overdose and suicidal ideation.
- Highlights the need for specialized clinical management strategies for CBP-related emergencies.
- Informs public health policy and harm reduction programs addressing stimulant abuse in Uruguay.
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