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Related Experiment Video

Updated: Jun 9, 2026

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[Mixed corneal dystrophy].

C Lange1, C Auw-Hädrich, D Böhringer

  • 1Institute of Ophthalmology, II-43 Bath Street, EC1V 9EL London, UK. clemens.lange@moorfields.nhs.uk

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|August 31, 2010
PubMed
Summary
This summary is machine-generated.

Phosphate-rich eye drops may cause calcium deposits mimicking lattice dystrophy in patients with Fuchs' corneal endothelial dystrophy. Caution is advised with these drops in certain eye conditions.

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Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Ocular Surface Disease

Background:

  • Fuchs' corneal endothelial dystrophy is a progressive condition affecting the cornea's inner lining.
  • Lattice dystrophy is another inherited corneal condition characterized by amyloid deposits in a lattice pattern.
  • Phosphate-rich eye drops are sometimes used for anti-inflammatory purposes.

Observation:

  • An 81-year-old patient presented with clinical features suggestive of combined Fuchs' and lattice dystrophy.
  • The patient had a history of treatment with anti-inflammatory phosphate-rich eye drops.
  • Histological examination of the corneal button revealed Fuchs' dystrophy but not lattice dystrophy.

Findings:

  • Microscopic analysis showed calcium deposits in the deep corneal stroma.
  • These calcium deposits formed a grid-like pattern, mimicking the appearance of lattice dystrophy.
  • Fuchs' corneal endothelial dystrophy was confirmed histologically.

Implications:

  • This case highlights that calcium deposits can present a pattern resembling lattice dystrophy.
  • It suggests a potential link between phosphate-containing eye drops and the formation of these deposits.
  • Prudent use of phosphate-containing eye drops is recommended for patients with chronic blepharoconjunctivitis and epithelial keratopathy.