Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Respiratory function and liver cirrhosis.

G Caruso1, D Catalano, A Corsaro

  • 1Cattedra di Terapia Media Sistematica, Università di Catania.

Rivista Europea Per Le Scienze Mediche E Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Europeenne Pour Les Sciences Medicales Et Pharmacologiques
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Domestic violence detection amid the COVID-19 pandemic: the value of the WHO questionnaire in emergency medicine.

QJM : monthly journal of the Association of Physicians·2020
Same author

An Italian pilot study of a psycho-social intervention to support family caregivers' engagement in taking care of patients with complex care needs: the Engage-in-Caring project.

BMC health services research·2019
Same author

Combined microwave thermal ablation and liver resection for single step treatment of otherwise unresectable colorectal liver metastases; a monoistitutional experiences.

European review for medical and pharmacological sciences·2014
Same author

Letter to the editor: Mostbeck G. Elastography everywhere--now even the lungs! Ultraschall in Med. 2014; 35: 5 - 8.

Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2014
Same author

Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism.

European review for medical and pharmacological sciences·2014
Same author

Resilience following spinal cord injury: a phenomenological view.

Spinal cord·2014
Same journal

Percutaneous management of benign renal cysts.

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques·1996
Same journal

Heparin induced thrombocytopenia after low molecular weight heparin treatment: a case report.

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques·1996
Same journal

Effective treatment of osteoarthritis with a 150 mg prolonged-release of diclofenac sodium.

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques·1996
Same journal

Transcranial Doppler validation of hemodynamic vertebrobasilar insufficiency diagnosis.

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques·1996
Same journal

Cardiovascular disease and Lp(a) in the adult population and in the elderly: the Brisighella study.

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques·1996
Same journal

HCV and dermatomyositis: report of 5 cases of dermatomyositis in patients with HCV infection.

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques·1996
See all related articles

Liver cirrhosis patients show altered respiratory function, particularly reduced peak expiratory flow rate (PEFR) and forced expiratory flow (FEF 25%). These changes, especially in small airways, may link to portal hypertension.

Area of Science:

  • Pulmonology
  • Hepatology
  • Internal Medicine

Background:

  • Liver cirrhosis can impact multiple organ systems.
  • Respiratory dysfunction is increasingly recognized in cirrhotic patients.
  • The specific mechanisms and patterns of respiratory impairment require further elucidation.

Purpose of the Study:

  • To investigate respiratory function in patients with liver cirrhosis.
  • To identify specific patterns of respiratory alteration based on cirrhosis severity and complications.
  • To explore the relationship between respiratory dysfunction and hemodynamic features of portal hypertension.

Main Methods:

  • Pulmonary function tests were performed on 27 liver cirrhosis patients and 36 healthy controls.
  • Patients were analyzed overall and in subgroups based on ascites, Child's class, albumin levels, bilirubin, alcohol etiology, and esophageal varices.

Related Experiment Videos

  • Specific parameters measured included PEFR, FEF 25%, FEF 25-75%, and FEF 75%.

    • Main Results:

    • Cirrhotic patients showed significantly reduced average PEFR and FEF 25% compared to controls.
    • Ascitic patients exhibited a significant reduction in PEFR.
    • Restrictive dysfunction was noted in Child's class C patients with hypoalbuminemia and hyperbilirubinemia.
    • Alcoholic cirrhotic patients displayed obstructive dysfunction.
    • Patients with esophageal varices had significantly decreased FEF 25-75% and FEF 75%, indicating small airway dysfunction, independent of ascites.

    Conclusions:

    • Liver cirrhosis is associated with significant alterations in respiratory function, including reduced airflow and small airway impairment.
    • Specific patterns of dysfunction (restrictive vs. obstructive) correlate with clinical and etiological factors of cirrhosis.
    • Small airway dysfunction in cirrhotic patients appears linked to the hemodynamic consequences of portal hypertension.