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[Variations of vasoactive intestinal peptide (VIP) concentration in the lung of asthmatic patients]
G Bottino1, P Moscatelli, G Antgognozzi
1ISMI - Instituto Scientifico di Medicina Interna, Genova.
Rivista Europea Per Le Scienze Mediche E Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Europeenne Pour Les Sciences Medicales Et Pharmacologiques
|April 1, 1990
Abstract:
The vasoactive intestinal peptide (VIP) concentrations in the pulmonary and systemic arterial blood were evaluated in 11 asthmatic patients in symptom-free period and during methacholin induced broncospasm. The basal venous and arterial mean values do not significantly differ. A significant difference was observed after bronchial challenge. This could be caused by an increased VIP pulmonary production as a defensive mechanism. No correlation was found between bronchial reactivity (as PD20-FEV1 Methacholin) and VIP concentrations.