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High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
Published on: March 5, 2022
A child with serious Chikungunya virus (CHIKV) infection requiring intensive care, after an outbreak
P Ramesh Menon1, Krishnan C, Jayaram Sankar
1Department of Pediatrics, Govt. TD Medical College, Alappuzha, Kerala, 688005, India. rpmpgi@gmail.com
Insights
A child with fever and breathlessness was diagnosed with myocarditis caused by Chikungunya virus (CHIKV). Prompt management led to full recovery, suggesting potential cardiac effects of CHIKV.
Area of Science:
- Pediatric infectious diseases
- Cardiology
- Virology
Background:
- Chikungunya virus (CHIKV) infection can present with diverse clinical manifestations.
- Cardiac involvement in CHIKV, particularly in pediatric cases, is not well-documented.
Observation:
- A 5-year-old boy presented with high-grade fever, cervical adenitis, myalgia, arthralgia, and acute breathlessness.
- Clinical, electrocardiographic, and echocardiographic findings indicated myocarditis and congestive cardiac failure.
Findings:
- Serum IgM antibodies to CHIKV were detected via MAC-IgM ELISA 5 days post-onset.
- The child showed symptomatic improvement within 3 days of conservative management.
- Repeat echocardiography at discharge revealed normal left ventricular function and mild mitral regurgitation.
Implications:
- This case highlights the potential for Chikungunya virus to cause significant cardiac complications in children.
- Early diagnosis and supportive care are crucial for managing CHIKV-induced myocarditis.
- Further research into the cardiac tropism of CHIKV is warranted.
Abstract:
A 5 1/2-yr-old boy presented with high grade fever for 4 days, and cervical adenitis, body ache, arthralgia, followed by sudden onset of breathlessness. He had clinical, electrocardiographic and echo evidence of myocarditis and congestive cardiac failure. An enzyme-linked immunosorbent assay (MAC-IgM ELISA) with serum collected 5 days after disease onset showed IgM antibodies to CHIKV. He was managed conservatively and started showing symptomatic improvement by 3 days. At discharge, a repeat Echocardiogram (a week later) showed normal left ventricular (LV) function with mild Mitral regurgitation. On follow up, after 2 months, child remains asymptomatic. Other common aetiological agents were screened for and found negative. This may indicate a probable cardiac tropism for the virus.
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