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Stereotactic transplantation of adrenal medullary tissue in Parkinson's disease

S S Chung1, S H Kim, D H Yoon

  • 1Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

Stereotactic and Functional Neurosurgery
|January 1, 1990
PubMed

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...