Hydroxyapatite nanoparticles: A review of preparation methodologies

Area of Science:

• Biomaterials Science
• Ceramic Engineering
• Nanotechnology

Background:

• Hydroxyapatite (HA) is a biocompatible ceramic, similar to mineral bone, used in medical applications.
• Mammalian bone comprises carbonated, substituted apatite nanocrystals within a collagen matrix, forming complex 3-D structures.
• There is increasing demand for synthetic bioactive ceramics that replicate natural bone apatite.

Purpose of the Study:

• To review established and novel precipitation methods for producing nanophased hydroxyapatite.
• To discuss the potential applications of hydroxyapatite nanoparticles in various medical fields.

Main Methods:

• Precipitation methods for synthesizing nanophased hydroxyapatite.
• Literature review of traditional and recent developments in HA nanoparticle synthesis and applications.

Main Results:

• Overview of various precipitation techniques for obtaining nanophased HA.
• Discussion of current and emerging applications for HA nanoparticles.

Conclusions:

• Nanophased hydroxyapatite can be synthesized using precipitation methods.
• HA nanoparticles hold significant promise for diverse biomedical applications, particularly in bone tissue engineering.