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Related Experiment Video

Updated: Jun 9, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Bone response to zinalco implants.

Ma C Pina¹, E Villareal, S Martin

¹Institute of Investigations on Materials, UNAM, University Town, Mexico City - Mexico.

Journal of Applied Biomaterials & Biomechanics : JABB

|August 31, 2010

Summary

This summary is machine-generated.

This study compared dog femur bone healing around steel and zinalco implants over 9 months. Zinalco corroded, causing disordered bone growth, but the body eventually normalized tissue proportions, though not shape or direction.

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Area of Science:

Biomaterials Science
Orthopedic Research
Veterinary Medicine

Background:

Biocompatibility of metallic implants is crucial for bone regeneration.
Understanding long-term in vivo material degradation and host response is essential.

Purpose of the Study:

To compare the in vivo bone response to steel and zinalco implants in canine femurs over 9 months.
To evaluate the degradation behavior of metallic implants and their effect on bone tissue evolution.

Main Methods:

Radiology, Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), and Fourier Transform Infrared Spectroscopy (FTIR) were employed.
In vivo implantation of steel and zinalco in dog femur models.

Main Results:

Zinalco exhibited corrosion, while steel remained largely unaltered in the physiological environment.
Continuous release of metal ions from zinalco promoted disordered bone growth with increased organic tissue.
After 9 months, bone mineralization normalized, but shape and directional growth remained abnormal.

Conclusions:

Zinalco's corrosion impacts bone healing, leading to initial tissue disorganization.
While the canine bone can compensate for mineralization defects, it cannot correct morphological abnormalities caused by implant degradation.