Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Freshwater Microbial Ecology01:24

Freshwater Microbial Ecology

Freshwater systems such as streams, rivers, and lakes exhibit distinct physical and biological characteristics that influence their microbial communities. These environments are broadly categorized into lotic systems—those with flowing waters like streams and most rivers—and lentic systems, which include still or slow-moving waters such as lakes, ponds, and marshes.In lentic systems, phytoplankton drive primary production, generating autochthonous organic carbon. In contrast, lotic systems...
Sound Waves: Resonance01:14

Sound Waves: Resonance

Resonance is produced depending on the boundary conditions imposed on a wave. Resonance can be produced in a string under tension with symmetrical boundary conditions (i.e., has a node at each end). A node is defined as a fixed point where the string does not move. The symmetrical boundary conditions result in some frequencies resonating and producing standing waves, while other frequencies interfere destructively. Sound waves can resonate in a hollow tube, and the frequencies of the sound...
Concept of Resonance and its Characteristics01:19

Concept of Resonance and its Characteristics

If a driven oscillator needs to resonate at a specific frequency, then very light damping is required. An example of light damping includes playing piano strings and many other musical instruments. Conversely, to achieve small-amplitude oscillations as in a car's suspension system, heavy damping is required. Heavy damping reduces the amplitude, but the tradeoff is that the system responds at more frequencies. Speed bumps and gravel roads prove that even a car's suspension system is not immune...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Sound Waves: Interference00:53

Sound Waves: Interference

Sound waves can be modeled either as longitudinal waves, wherein the molecules of the medium oscillate around an equilibrium position, or as pressure waves. When two identical waves from the same source superimpose on each other, the combination of two crests or two troughs results in amplitude reinforcement known as constructive interference. If two identical waves, that are initially in phase, become out of phase because of different path lengths, the combination of crests with troughs...
Body Water Content and Fluid Compartments01:19

Body Water Content and Fluid Compartments

Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions (Na+) and chloride...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of putative hepatoprotective agents as an adjunct to anti-TB treatment in Europe.

IJTLD open·2025
Same author

Treatment of progressive locally advanced and metastatic basal cell carcinoma after two lines of treatment with hedgehog inhibitors and anti-PD1: The role of sonidegib rechallenge.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Treatment of psoriasis with biologic and non-biologic targeted therapies in patients with latent tuberculosis infection or at risk for tuberculosis disease progression: Recommendations from a SPIN-FRT expert consensus.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

New onset of guttate psoriasis, Hallopeau's continuous acrodermatitis, and psoriatic arthritis after COVID-19 vaccine.

Scandinavian journal of rheumatology·2024
Same author

Identifying gaps in the cascade of care for latent TB infection in a low-incidence setting.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
Same author

Musculoskeletal tissues-on-a-chip: role of natural polymers in reproducing tissue-specific microenvironments.

Biofabrication·2022

Related Experiment Video

Updated: Jun 9, 2026

Long-term Behavioral Tracking of Freely Swimming Weakly Electric Fish
10:56

Long-term Behavioral Tracking of Freely Swimming Weakly Electric Fish

Published on: March 6, 2014

Hydrothane(R) interactions with biological components: a comparison with Chronoflex(R).

M Santin1, M A Wassall, L Ambrosio

  • 1School of Pharmacy and Biomolecular Sciences, Brighton University, UK.

Journal of Applied Biomaterials & Biomechanics : JABB
|August 31, 2010
PubMed
Summary

Hydrothane, a polyurethane, showed lower protein and cell adhesion compared to Chronoflex, indicating its potential for biomedical applications. This biomaterial interaction study highlights Hydrothane

More Related Videos

Continuous Hydrologic and Water Quality Monitoring of Vernal Ponds
06:37

Continuous Hydrologic and Water Quality Monitoring of Vernal Ponds

Published on: November 13, 2017

A Stable Phantom Material for Optical and Acoustic Imaging
04:54

A Stable Phantom Material for Optical and Acoustic Imaging

Published on: June 16, 2023

Related Experiment Videos

Last Updated: Jun 9, 2026

Long-term Behavioral Tracking of Freely Swimming Weakly Electric Fish
10:56

Long-term Behavioral Tracking of Freely Swimming Weakly Electric Fish

Published on: March 6, 2014

Continuous Hydrologic and Water Quality Monitoring of Vernal Ponds
06:37

Continuous Hydrologic and Water Quality Monitoring of Vernal Ponds

Published on: November 13, 2017

A Stable Phantom Material for Optical and Acoustic Imaging
04:54

A Stable Phantom Material for Optical and Acoustic Imaging

Published on: June 16, 2023

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Biocompatibility Studies

Background:

  • Polyurethanes are widely used in biomedical devices.
  • Understanding surface interactions is crucial for biocompatibility.
  • Hydrothane and Chronoflex are two polyurethanes with different properties.

Purpose of the Study:

  • To assess the protein adsorption and cell/bacterial adhesion on Hydrothane.
  • To compare Hydrothane's performance with Chronoflex.
  • To elucidate the surface properties influencing these interactions.

Main Methods:

  • Dynamic contact angle (DCA) measurements.
  • Protein adsorption assays (including immunoblotting).
  • Fibroblast and Pseudomonas aeruginosa adhesion tests.

Main Results:

  • Hydrothane exhibited lower protein binding and cell adhesion than Chronoflex.
  • Hydrophobic domains on Hydrothane's surface influenced protein adsorption.
  • Adsorbed proteins on Hydrothane included human serum albumin (HSA) and á 1-microglobulin (á 1-m).
  • Complement C3 fragment showed altered profiles, suggesting activation.
  • Reduced adhesion correlated with lower binding of proteins like fibronectin.

Conclusions:

  • Hydrothane demonstrates improved biocompatibility due to reduced protein adsorption and cell adhesion.
  • Surface characteristics of Hydrothane influence its interaction with biological components.
  • These findings support Hydrothane's potential use in medical devices where reduced biofouling is desired.